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The clinical evidence for Rhodiola rosea is supported by multiple randomized, double-blind, placebo-controlled trials, including a phase III study evaluating the standardized extract SHR-5, which demonstrated statistically significant improvements in depressive symptoms with a favorable tolerability profile

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Furthermore, this HG concentration was associated with a sustained increase in ROS generation (up to 96 h), suggesting it effectively induces oxidative stress, partly due to the simultaneous disruption of the antioxidant defense system [23]