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An FDA advisory panel will discuss whether to loosen restrictions on seven peptides

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At difficult coupling steps (e.g., for phosphorylated serine or threonine), an additional capping step was introduced

Their review argued that the original sequence determination was performed once and not re-verified by modern methods, and that endogenous DSIP-like immunoreactivity in mammalian tissue may reflect related peptides rather than the synthetic nonapeptide as drawn (Kovalzon & Strekalova, 2006)