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In the past years, there has been notable progress in understanding the transcript expression profile during salinity adaptation of various euryhaline teleost species using RNA-Seq, such as Nile tilapia ( Oreochromis niloticus ), Mozambique tilapia ( Oreochromis mossambicus ) ( Table 2 ) (Ronkin et al., 2015), medaka ( Oryzias melastigma ) (Lai et al., 2015), striped catfish ( Pangasianodon hypophthalmus ) (Thanh et al., 2015

This, in turn, upregulates SLC7A11 expression, enhances the levels of GPX4, GSH, and SOD, and reduces Fe 2+ and MDA levels, thereby suppressing ferroptosis and promoting BV2 cell survival

The determination rock climbers have to go higher and harder is the same determination we should each resolve in our lives: see that there is room to grow, and use challenges to be better, stronger, and more resilient

7 Future perspectives Model organisms are important substitutes for human studies to facilitate and expedite translation of preclinical studies