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Given its anti-inflammatory potential, Thymulin downregulates the release of inflammatory mediators, such as cytokines and chemokines, upregulates anti-inflammatory factors, such as interleukin (IL)-10, and exerts molecular control via the regulation of transcription factors and mediators

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34 Moreover, histamine inhibits neutrophil chemotaxis by acting on its type 2 receptor (H 2 ) hence an effect mimicked by the H 2 agonist impromidine, but not by the H 1 agonist betahistine

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