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APR-017 treatment led to increased ROS level and decreased GSH level in PDCs with low expression of VRK2 rather than PDCs with high expression of VRK2 (Fig

NAD + is also involved in nucleotide and amino acid synthesis, such as the folate-dependent serine catabolism 347 , as well as genomic DNA replication, as reviewed above 118

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We next visualized the same paired loci in the cnd1-K658E mutant and found that the shortening of the intra-domain probe distances observed in wild-type cells during mitosis was significantly compromised in the mutant, indicating that domain-based chromosome compaction during mitosis is impaired in the cnd1-K658E mutant (Fig