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Histopathological Examination of the Testis to Directly Assess the Seminiferous Tubules of the Testis as the Gold Standard for Assessment of Spermatogenic Function of the Testis Compared with group A, the basement membrane of the seminiferous tubules of the testis tissue in group B was atrophied, thinned, wrinkled and stratified based on HE staining

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They highlight that tumor-generated lactic acid acidifies the microenvironment, which, in the presence of TGF-, fosters Treg development via enhanced lactylation of proteins like moesin that bolster TGF- receptor signaling (155)