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FGF21, by binding to its receptor FGFR1, activates the downstream PI3K/AKT signaling pathway, inhibits the activation of the inositol-requiring enzyme 1 (IRE1)/JNK pathway, and reduces the expression of apoptosis-related proteins such as C/EBP-homologous protein (CHOP) and claved-caspase3, thereby suppressing oxidative stress and apoptosis

International agencies, including the World Health Organization (WHO), regard antimicrobial resistance as one of the most significant threats to public health worldwide

[5] Sulfhydryl groups can be oxidised up to three times by three HClO molecules, forming sulfenic acids, sulfinic acids and RSO 3 H, which are increasingly irreversible and bactericidal

95% CI, 3.71011.238