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68,69 Once the cationic molecules contact with the endothelial cell surface, they adhere to it by adsorption

Fluvastatin and lovastatin target the cholesterol pathway that plays a role in the prenylation of members of the PI3K/AKT/mTOR pathway and RAS, which could impact on the ability of RAS to activate BRAF [67], eventually causing a proliferation arrest

Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47(phox)

On the other hand, 22 metabolic pathways were significantly downregulated in GDH3 -deleted cells cultured in MM medium and only oxidative phosphorylation, sulphur metabolism, biotin metabolism, pyrimidine metabolism, and glycolysis/gluconeogenesis were upregulated