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BMJ 2010;340:c365

Abecma and Carvykti are available only through a Risk Evaluation and Mitigation Strategies (REMS) program due to the risk of cytokine release syndrome and neurologic toxicities

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Studies also show that insulin alone cannot effectively manage diabetes because it doesn't address GCG's catabolic effects, whereas treatments targeting GCG suppression, such as leptin or GCG receptor antibodies, could lead to better glucose regulation