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Selective suppression of hippocampal ripples impairs spatial memory

(B) Functionality of the dCas9-based transcriptional repressor is demonstrated by a 5.7-fold decrease in CD81 protein expression (red histogram) compared to non-targeting gRNA controls (grey histogram), measured by geometric mean fluorescence intensity (GMFI) in the GFP+ population

(2025), astrocytes gene signatures are upregulated during the early symptomatic stage, characterized by proliferation, and subsequently they decline as pro-inflammatory genes become upregulated during disease progression in TDP-43 mouse model