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Homeostasis of the astrocytic glutamate transporter GLT-1 is altered in mouse models of Lafora disease

Clin Pharmacol Ther 81(5):692698 Ricke KM et al (2020) Mitochondrial dysfunction combined with high calcium load leads to impaired antioxidant defense underlying the selective loss of nigral dopaminergic neurons

46 AAV vectors are derived from the non-pathogenic parvovirus, AAV, which has the advantage of minimally integrating into the host genome, thereby reducing the risk of insertional mutagenesis