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Description

Reactions were performed with 0.5 M catechol substrate COMT-S01, 1 M radiolabelled S-adenosyl-L-[methyl-3H] methionine (SAM) co-substrate, and recombinant human COMT enzyme

in diet-induced obese mice, 5-Amino-1-MQ significantly reduces total body weight, fat mass, and adipocyte size, while improving insulin sensitivity and glucose tolerance 2,3