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Continued progress will depend on technologies such as single-cell multi-omics, spatial proteogenomics, intravital imaging of iron flux, and ferroptosis-reporter mouse models, which can resolve these interactions with high precision

It is also very necessary to identify if TMAO contributes to chondrocytes injury through modulating the classical pathways of ferroptosis such as ACSL4/GPX4 or other specific pathways, such as those of iron-related proteins, lipid peroxidation products, and other sensitivities to mechanical stimulation

P = 0.91)

VaccarinoVShahAJMehtaPKPearceBRaggiPBremnerJDet alBrain-heart connections in stress and cardiovascular disease: implications for the cardiac patient