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99m Tc-conjugated RP527 peptide (VPLPAGGGTVLTKMYPRGNHWAVGHLM), a GRP analog, has been exploited for treating human malignancies, including colon and prostate carcinomas 69

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Various factors influence the radio-resistance of CSCs, including the degree of DNA damage, detection of reactive oxygen species (ROS), and glutathione (GSH) contents 4,6,7 DNA damage is one of the most effective mechanisms by which ionizing radiation leads to tumor cell death, 8 and DNA double-strand breaks (DSBs) are believed to cause major DNA damage in radiation therapy 9 p53binding protein 1 (53BP1) is an important component of DSB signaling and facilitates the nonhomologous end-joining (NHEJ)-mediated DSB repair