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The protein similarity somehow reflects the gene arrangement since PtGSTF1 and PtGSTF2 genes are present in tandem on chromosome 2, PtGSTF4 , 5, 6, and 7 genes cluster on the scaffold 36, whereas PtGSTF3 and PtGSTF8 are found at isolated loci on the chromosomes 14 and 17, respectively

An enormous challenge in such animal models is to establish the relevance of the mechanisms elucidated to OCD in humans

Pathway analysis of siGSTO1 Bru-Seq data was also performed using IPA (Ingenuity Systems, Inc., Redwood City, CA) with genes showing fold change 2