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for example, the TLR4/NF-B/IL-1 signaling pathway is activated in chronic SZ patients (197), and clozapine reduces the expression of pro-inflammatory genes such as IL-1 and IL-6 by inhibiting the TLR4/NF-B pathway (198)

Nutritional strategies that favor caloric moderation and healthier fat profiles lower ER secretory stress, reduce peroxisomemitochondria mismatch and diminish LIP-driven Fenton risk, while ensuring selenium sufficiency supports GPX4 and ferroptosis control (Matai et al