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Based on structural models, it can be assumed that the MT molecule is composed of two binding domains, and , which are composed of Cys-clusters

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Mutations in IDH cause the loss of its enzymatic activity of converting isocitrate to -KG while conferring a neo-enzymatic activity of reducing -KG to the oncometabolite D-2-hydroxyglutarate, an excess of which favors the formation of malignant tumors (86)