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Compound 102 exhibited overt suppression of ROS accumulation in a dose-dependent manner with an EC 50 of about 11.4 M (fluorescent intensity determined by ImageJ and a plate reader, Supplementary Figures S7 , S8 )

These findings suggest that managing cellular copper levels through metabolic reprogramming is a simple way to switch the main energy metabolism pathway of cells between glycolysis and oxidative phosphorylation (OXPHOS) to control cell fate