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J Biol Chem 281:1801518024

Overpronation, pes cavus, and restricted foot dorsiflexion are common with this condition, although foot pronation itself has not been demonstrated to be a predisposing factor

In vitro studies revealed that diminishing NNMT expression via RNA interference (RNAi) and inhibiting NNMT with MNAM substantially augmented oxygen consumption (OC) in adipocytes