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One has to keep in mind that leptin takes part in the pathophysiology of both asthma and obesity and that outcomes of these diseases may overlap, especially in the context of lung function [156,192,193,194]

For example, intradiscal injection of bone morphogenetic protein-2 (BMP-2) induced degenerative changes [92] and weekly intradiscal treatment with growth and differentiation factor-5 (GDF-5) or insulin-like growth factor-1 (IGF-1) resulted in inflammatory reactions in the adjacent vertebrae and connective tissue infiltrates in the NP, causing the IVD to collapse [93]

As with every product in our catalog, it is sold for research purposes only , with an emphasis on purity expectations and laboratory-grade handling practices

Source data underlying graphs and charts presented figures can be found in Supplementary Data 1