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446,448 Although fMLP also activated PI3K to a lesser extent than CXCL8-induced expression, the concomitant addition of chemokines and fMLP resulted in the inhibition of PI3K activity, indicating that the p38 MAPK pathway may inhibit the PI3K pathway (Fig

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Few evidence showed that I148M overexpression in hepatoma cells correlated with metabolic switching and mitochondrial (mt) dysfunction