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Prospective clinical application of circulating cell-free DNA sequencing in metastatic colorectal cancer 75(15S), 2015

K.CamilloC

Other strategies designed to restore NAD + levels in human disease are focused on the modulation of enzymes involved in NAD + homeostasis, either via amplification of NAD + synthesis through the de novo , Preiss-Handler or salvage pathways, or blockade of NAD + consumption by the three main families of NAD + -consuming enzymes: sirtuins, poly(ADP-ribose) polymerases (PARPs), and cyclic ADP(cADP)-ribose synthases [16,17,18]