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Furthermore, the classical PKA motif is RRx[S*/T*] and has in 2 position of Ser16 a lysine (K) and not arginine (R), which can also serve as a PKD motif (Pinna & Ruzzene, 1996)

Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain

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