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PLLA was first FDA-approved in 2004 for HIV lipoatrophy, but was quickly adopted for off-label use in the immunocompetent population for facial rejuvenation

THERE IS NO SUBSTANTIAL EVIDENCE THAT IT INCREASES WEIGHT LOSS BEYOND THAT RESULTING FROM CALORIC RESTRICTION, THAT IT CAUSES A MORE ATTRACTIVE OR "NORMAL" DISTRIBUTION OF FAT, OR THAT IT DECREASES THE HUNGER AND DISCOMFORT ASSOCIATED WITH CALORIE-RESTRICTED DIETS

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27 Although the general public and commercial health food suppliers have a seemingly insatiable appetite for fountain of youth dietary supplements, it seems premature to recommend mandatory fortification of the food supply without well-conducted, randomized clinical trials