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MRI predictors of pharmacotherapy response in major depressive disorder,

Wang C, Zhu H, Sun Z, Xiang Z, Ge Y, Ni C, et al

"Northwestern Health Sciences University ~ Diagnosis and Discussion"

work showing that clock genes control G1/S progression by transcriptionally regulating Cdkn1a a gene encoding for the cyclin/Cdk inhibitor p12 WAF1/CIP1 and that alteration of circadian clock led to aberrant p21 expression and altered cellular proliferation 30