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Using both MRI and TMS , this project addresses two main research questions: 1)What is the impact of individual cortical lesions, specifically in the primary sensorimotor hand area, on hand dexterity in different subtypes of MS 2) What role do focal and diffuse cortical myelin changes play in relation to physical and cognitive function in primary progressive MS In close collaboration with the Danish Multiple Sclerosis Center at Rigshospitalet Glostrup, we are in the unique position to investigate these questions in MS patients at all stages of the disease