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In vitro exposure to SeNP can increase levels of H3K4me3, H3K27me3, and H3K9me2 [40], and decrease H3K9me3 methylation [61], imparting a global rather than specific effect on histone methylation

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NNMT inhibition may actually improve the adipocytes capacity to oxidize fat by restoring the NAD+-dependent sirtuin activity and mitochondrial function that fatty acid oxidation requires

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