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The paired nature of the experimental design was considered in the model as an adjusting factor

We note that under our proposal, an ACO may use prepaid shared savings for staffing, healthcare infrastructure and direct beneficiary services in a manner that complies with the beneficiary incentives provision at 425.304(a), (b), and newly proposed (d) as discussed in section III.G.5.i of this final rule, and all other applicable laws and regulations

Additionally, ZIP8, ZIP9, and ZIP13 have been demonstrated to be upregulated in BrM2 cells