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Concurrently, M1 macrophages possess the ability to activate NK T cells to secrete IFN-, thus accelerating the development of early-stage atherosclerosis (134)

In spite of the development of various chemotherapy regimens in the treatment of breast cancer, the drug resistance has been a problematic issue in the treatment of this malignant disease

The long-term effects of chronic use on the endocrine system have not been formally investigated

Concentrations of drug equal to or greater than the MIC for many pathogens (See Tables I, II and III) are reached in most tissues by two hours after dosing at 2.5 mg/kg and are maintained for 8-12 hours after dosing