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Reversal experiments confirmed that suppression of NLRP3 expression significantly attenuated the anti-inflammatory effects of AS-IV, indicating that its effects are dependent on the regulation of the NLRP3 pathway

That's the double-edged sword in a sentence: the same property that makes IGF-1 LR3 powerful for stimulating muscle growth also removes the natural brakes that normally keep IGF-1 signaling safe

10.3969/j.issn.1674-4616.2013.06.002 313 WanzolaM.FurutaT.KohnoY.FukumitsuS.YasukochiS.WatariK.et al (2010)

DLK-1, SEK-3 and PMK-3 are required for the life extension induced by mitochondrial bioenergetic disruption in C