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Goetzl EJ, Yao PJ, Kapogiannis D

New York: Taylor and Francis

REST directly binds to the promoter region of glutamate-cysteine ligase (GCLM), inhibits the synthesis of GSH through transcriptional inhibition of GCLM expression, and induces ferroptosis

However, dysfunction of IDO2 in combination with tryptophan inhibition of IDO1 results in increased cytosolic tryptophan, reduced kynurenine production and downstream metabolites including quinolinate and NAD +