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Certain medical conditions and medications increase B12 requirements: Long-term use of metformin (diabetes medication) or proton pump inhibitors (PPIs for acid reflux) can impair B12 absorption [13] [14] Gastrointestinal conditions such as Crohn's disease, coeliac disease, or previous gastric surgery Autoimmune conditions beyond pernicious anaemia may affect B12 metabolism When to contact your GP : If you are taking B12 supplements or receiving injections but continue to experience symptoms, request a review

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Similar content being viewed by others Introduction The Human Genome project started in 1990 and it was completed in 2004 (the first draft of the genome was submitted in 2001) [1,2,3], paving the way for the 1000 Genomes Project, which was initiated in 2007 with the aim of sequencing 1000 genomes