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The isozyme and receptor subtypes can be identified with gene expression analyses of patient muscle samples, and their cellular localization can be determined with immunohistochemical staining, although muscle biopsies are rarely performed following the implementation of genetic testing for the definitive diagnosis of FCMD

ROS also are involved in the onset, promotion, and advancement phases of tumor growth

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Zhang et al (67) reduced neutrophil recruitment and ROS production by using single-stranded oligonucleotides with high affinity for C5a, coupled to nanoparticles, thus alleviating inflammation and damage associated with HIRI