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Biotin is subsequently generated through the combination of these pathways in a four-step process (148)

Nonetheless, targeting the FABP5GPX4 axis could represent a novel adjunct strategy to potentiate current biologics, reduce required dosages, and mitigate side effects

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Some important gaps in the development of anti-CSC drugs should be reconsidered, since most of the compounds tested in preclinical models have not been subjected to clinical trials