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In summary, during DKD, Nrf2 expression is downregulated while p53, STAT1, and TGF-1 expressions are upregulated

A comparative analysis between different metal-doped (including Ce-doped, Cr-doped, Cu-doped, Fe-doped, and Mn-doped CDs) and non-metal-doped CDs as peroxidase-mimics has also been reported (Yuxin et al., 2022)