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As the silk matrix gradually degrades, both components are released steadily, avoiding abrupt spikes in drug concentration

Grapeseed oil is generally well tolerated, but patients with known seed or nut oil allergies should discuss alternatives with their pharmacist

These effects could be more pronounced with concomitant use of oxycodone and acetaminophen tablets and CYP3A4 and CYP2D6 inhibitors, particularly when an inhibitor is added after a stable dose of oxycodone and acetaminophen tablets is achieved [see WARNINGS]

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