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Medicine (Baltimore) 2021;100(6):e24590

Key Takeaways IGF1 LR3 is a lengthened and more stable version of IGF1

In contrast, Rapa uniquely regulated pathways linked to PI3K-Akt signaling, reflecting feedback-driven reprogramming post-mTOR inhibition, alongside autophagy-apoptosis crosstalk driving metabolic remodeling (Fig