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When the proteins change shape they are able to bind to ionic (charged) nutrients and deposit them on the opposite side of the membrane, which, in turn, causes another change in protein shape and results in another transport of ions, this time in the other direction

2016;11:e0154337

Ultimately, mitochondrial damage results in the release of cytochrome C into the cytoplasm, activating Caspase-9 and triggering intrinsic apoptosis (Fig