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The results from this study indicated that astrocyte-targeting strategy (AST) clearly protected neurons from MPTP neurotoxin in both the young and aged groups, while the effect of AST was less pronounced in older mice, since it could not prevent the decrease in tyrosine hydroxylase (TH) in the nigrostriatal pathway ( In vitro , AST significantly improved the viability of SH-SY5Y cells exposed to paraquat by dampening oxidative stress and curbing apoptosis

The PRNP promoter contains metal-responsive elements that are targeted by the metal-sensitive transcription factor MTF1, which transactivates PRNP in response to Cu 23

Resolvin E1 (RvE1), a metabolite of eicosapentaenoic acid (EPA), is a mediator that promotes lipid metabolism [101]

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