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The World Health organisation (WHO) estimates that approximately 552 million adults are expected to have diabetes by 2030, and diabetes-related cognitive dysfunction is likely to be a major challenge in terms of future health resource requirements (3, 4) (Figure 1)

Therapeutic features and updated clinical trials of mesenchymal stem cell (MSC)-Derived exosomes

Diabetes Care 25 (8), 14441450

In addition, other cytotoxic or lytic peptides, such as defensin 1 (ACYCRIPACIAGERRYGTCIYQGRLWAFCC), cecropin B (KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKAL), magainins (GIGKFLHSAKKFGKAFVGEIMSNS), and dermaseptin (ALWKEVLKNAGKAALNEINNLVG), can increase membrane permeability and promote cell death 60,61