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The WHI used synthetic conjugated equine estrogens plus medroxyprogesterone acetate in women who were on average 63 years old over a decade past menopause

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In fact, FMO1 is also participated in the oxidization of TMA to TMAO, however, its specific activity is only 1/10 that of FMO3 ( Numerous studies indicate that inhibition of FMOs, especially FMO3, is an effective target for reducing TMAO concentrations (Zhu et al., 2018