The aim of this study was to investigate the role of antioxidant treatment with l-carnitine in oxidative stress and platelet activation in patients undergoing major abdominal surgery
Considering the evidence addressing the ameliorating effects of either L-carnitine or biotics on metabolic indices, also the reports addressing higher efficacy of concomitant supplementation versus single-therapies, this clinical trial was conducted to assess the effects of L-carnitine + multi-species/multi-strain synbiotic combined supplementation compared to L-carnitine mono-therapy on atherogenic-indices, body composition, visceral obesity, and appetite sensations in 46 metabolically healthy women with obesity, randomly assigned to co-supplementation (L-carnitine-tartrate (2 500 mg/dl) + synbiotic (one capsule/day)) or mono-therapy (L-carnitine-tartrate (2 500 mg/dl) + maltodextrin (one capsule/day)) groups for 8 weeks
Dietary modifications and supportive therapies may also be necessary to manage symptoms and prevent complications
Data extracted from the selected studies included study design, sample size, form and dosage of carnitine supplementation, duration of intervention, and reported outcomes (e.g., effects on inflammatory markers, anemia, lipid profile)