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We recommend using the smallest appropriate gauge, typically 23-25g

An additional clinical concern is whether heterogeneous BBB leakage in AD could lead to disproportionate nanoparticle accumulation in regions of increased permeability, thereby increasing the risk of local neurovascular toxicity (Montagne et al., 2020)

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This could contribute to liver diseases such as cirrhosis , which involves liver scarring and loss of function