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It has been demonstrated that peroxynitrite formation subsequent to APAP overdose is independent of inducible nitric oxide synthase (iNOS) [42]

At the same time different neural cells perform distinct functions: more that five hundred million years of nervous system evolution segregated neural cells into electrically excitable neurones responsible for input/output information transfer and information processing and electrically non-excitable neuroglia, 2,3,4 which provide homoeostatic support and defence of the nervous tissue

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However, H3Q5 dopaminylation findings remain heterogeneous across drugs and experimental paradigms, and, notably, no studies to date have established a direct role for this modification in depressive pathology (Table 2)